Across TCGA pan-cancer cohorts, RNU4-1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RNU4-1’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU4-1 RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4-1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
THCA, UCEC, and KIRC are the cancer types where RNU4-1 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-1 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.