RNF6

Across TCGA cell cohorts, RNF6 mutation is significantly associated with the RNA expression of many other genes, with 249 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF6-associated genes across cancer lineages are H2BC1, H2AC1, and OR8A1. Each is linked with RNF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF6-to-partner and partner-to-RNF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by RNF6-low versus RNF6-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF6→partner) and Y-score (partner→RNF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.145	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR8A1 →	+0.296	+4.417	.003	.004	3	1
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
BLOOD_Leukemia	KRTAP5-6 →	+0.333	+4.874	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

H2BC1 by RNF6 expression — SOFT_TISSUE

Explore this box plot interactively →