RNF4

Across TCGA cell cohorts, RNF4 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF4-associated genes across cancer lineages are KIR2DL4, TRAT1, and IAPP. Each is linked with RNF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF4-to-partner and partner-to-RNF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR2DL4 grouped by RNF4-low versus RNF4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF4→partner) and Y-score (partner→RNF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KIR2DL4 →	+0.171	+4.491	<.001	.003	3	2
SKIN	TRAT1 →	+0.060	+4.054	<.001	.004	3	2
LARGE_INTESTINE	IAPP →	+0.466	+4.228	<.001	.001	3	2
LARGE_INTESTINE	OR2C1 →	+0.156	+3.578	<.001	.006	3	2
PANCREAS	IL26 →	+0.095	+4.237	<.001	.006	3	1
PANCREAS	IGSF21 →	+0.041	+4.491	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

KIR2DL4 by RNF4 expression — PANCREAS

Explore this box plot interactively →