RNF4

Across TCGA pan-cancer cohorts, RNF4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RNF4 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher RNF4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNF4 expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

KICH, UCS, and SCLC are the cancer types where RNF4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	III,IV	0.178	1.000	.003	46	view →
UCS	OS	Median	III,IV	0.773	0.375	.002	46	view →
SCLC	OS	Quartile	All	0.690	0.344	.003	38	view →
KIRP	OS	Median	All	0.910	0.979	.005	36	view →
LUAD	DFS	Tertile	All	0.741	0.840	.007	35	view →
LIHC	OS	Quartile	All	0.571	0.772	.001	33	view →
UVM	DFS	Quartile	II,III,IV	0.229	0.751	.001	30	view →
PAAD	OS	Median	II,III,IV	0.686	0.402	<.001	19	view →
ACC	DFS	Quartile	All	0.314	0.784	.002	17	view →
LGG	OS	Tertile	All	0.734	0.865	.001	16	view →
UCEC	OS	Median	III,IV	0.892	0.759	.012	16	view →
SARC	OS	Tertile	All	0.360	0.751	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RNF4–KICH (DFS)

Open the KICH breakdown →