RNF34

Across TCGA patient cohorts, RNF34 mutation is significantly associated with the RNA expression of many other genes, with 913 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF34-associated genes across cancer lineages are TRIM51HP, OR8B1P, and TRGJP2. Each is linked with RNF34 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF34-to-partner and partner-to-RNF34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM51HP grouped by RNF34-low versus RNF34-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF34→partner) and Y-score (partner→RNF34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TRIM51HP →	+0.082	+5.279	<.001	.006	3	2
BLCA	OR8B1P →	+0.108	+5.411	<.001	.005	3	2
UCEC	TRGJP2 →	+0.593	+2.236	<.001	.002	3	2
UCEC	LINC02528 →	+0.341	+2.807	<.001	<.001	3	2
BLCA	WBP1LP6 →	+0.170	+6.814	<.001	<.001	3	1
UCEC	PAMR1 →	-0.960	-3.443	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 913 associations by consensus.

TRIM51HP by RNF34 expression — LUAD

Explore this box plot interactively →