RNF34

Across TCGA pan-cancer cohorts, RNF34 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF34’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF34 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF34 is over-expressed in tumor.

HNSC, KIRC, and LIHC are the cancer types where RNF34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.981	<.001	12	view →
KIRC	All	IV	+0.447	<.001	11	view →
LIHC	Female	III,IV	+1.084	<.001	9	view →
KIRP	All	II,III,IV	+0.565	<.001	9	view →
LUAD	Male	II,III,IV	+0.790	<.001	8	view →
LUSC	Female	All	+0.654	<.001	8	view →
COAD	Female	II,III,IV	+0.588	<.001	8	view →
BLCA	All	III,IV	+0.544	<.001	8	view →
STAD	All	II,III,IV	+0.724	<.001	7	view →
UCEC	All	III,IV	+0.627	<.001	6	view →
BRCA	All	III,IV	+0.563	<.001	6	view →
CHOL	Male	All	+2.161	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF34–HNSC

Open the HNSC breakdown →