RNF34

Across TCGA cell cohorts, RNF34 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF34-associated genes across cancer lineages are TBC1D3, PRKAG3, and LRCH2. Each is linked with RNF34 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF34-to-partner and partner-to-RNF34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by RNF34-low versus RNF34-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF34→partner) and Y-score (partner→RNF34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.091	+4.273	<.001	.006	3	1
BLOOD_Leukemia	PRKAG3 →	+0.035	+3.551	<.001	.009	3	1
BLOOD_Leukemia	LRCH2 →	+0.581	+3.807	<.001	.007	3	1
BLOOD_Leukemia	MMP20 →	+0.048	+3.705	<.001	.007	3	1
BLOOD_Leukemia	CYP1A2 →	+0.043	+4.125	<.001	.008	3	1
BLOOD_Leukemia	LRIT1 →	+0.032	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TBC1D3 by RNF34 expression — LARGE_INTESTINE

Explore this box plot interactively →