RNF31

Across TCGA cell cohorts, RNF31 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNF31-associated genes across cancer lineages are OR2C1, R3HDML, and BANF2. Each is linked with RNF31 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF31-to-partner and partner-to-RNF31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2C1 grouped by RNF31-low versus RNF31-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF31→partner) and Y-score (partner→RNF31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR2C1 →	+0.125	+4.047	<.001	.001	3	2
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	BANF2 →	+0.047	+5.643	<.001	.002	3	1
BREAST	REG1B →	+1.039	+5.169	<.001	.005	3	1
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
OVARY	SOX1 →	+0.786	+4.187	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

OR2C1 by RNF31 expression — LARGE_INTESTINE

Explore this box plot interactively →