RNF31

Across TCGA pan-cancer cohorts, RNF31 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNF31’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF31 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, LIHC, and THCA are the cancer types where RNF31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.512	<.001	8	view →
LIHC	Female	II,III,IV	+1.228	<.001	7	view →
THCA	All	All	−0.383	.001	7	view →
CHOL	All	All	+1.991	<.001	5	view →
STAD	All	II,III,IV	+0.659	.002	4	view →
BLCA	All	All	+0.446	.011	3	view →
KIRC	All	II,III,IV	−0.292	.011	2	view →
COAD	All	All	+0.195	.011	2	view →
ESCA	All	All	+0.573	.010	1	view →
LUAD	All	All	+0.182	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNF31–HNSC

Open the HNSC breakdown →