RNF217-AS1

Across TCGA patient cohorts, RNF217-AS1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF217-AS1-associated genes across cancer lineages are eIF4E, ASNS, and ACVRL1. Each is linked with RNF217-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF217-AS1-to-partner and partner-to-RNF217-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RNF217-AS1-low versus RNF217-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF217-AS1→partner) and Y-score (partner→RNF217-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.245	+3.700	.012	.001	3	2
UCEC	ASNS →	+0.652	+2.321	<.001	.034	3	2
SKCM	ACVRL1 →	+0.189	+2.840	.012	.033	3	1
SKCM	PI3K-p85 →	-0.293	-3.169	.010	.019	3	1
SKCM	Src →	-0.352	-3.169	.004	.019	3	1
SKCM	Di-Ras3 →	+0.199	+2.820	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by RNF217-AS1 expression — UCEC

Explore this box plot interactively →