RNF217-AS1

Across TCGA pan-cancer cohorts, RNF217-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RNF217-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF217-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF217-AS1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where RNF217-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF217-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.789	<.001	11	view →
KIRP	All	II,III,IV	+0.246	<.001	11	view →
KICH	Male	All	−0.249	<.001	7	view →
THCA	Male	II,III,IV	−0.552	<.001	6	view →
LUSC	All	II,III,IV	+0.536	<.001	6	view →
BRCA	All	III,IV	−0.425	<.001	6	view →
UCEC	All	All	−0.293	<.001	6	view →
STAD	All	All	−0.196	.001	6	view →
READ	All	All	−0.471	.002	5	view →
LUAD	Female	III,IV	−0.254	<.001	3	view →
LIHC	Male	All	+0.091	.006	3	view →
PRAD	All	All	−0.274	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RNF217-AS1–HNSC

Open the HNSC breakdown →