RNF215

Across TCGA patient cohorts, RNF215 mutation is significantly associated with the RNA expression of many other genes, with 2,314 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF215-associated genes across cancer lineages are RNU6-589P, RN7SKP169, and DNAJA1P1. Each is linked with RNF215 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF215-to-partner and partner-to-RNF215 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-589P grouped by RNF215-low versus RNF215-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF215→partner) and Y-score (partner→RNF215) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-589P →	+0.413	+4.705	<.001	.003	3	2
SKCM	RN7SKP169 →	+0.164	+6.469	<.001	.001	3	2
BLCA	DNAJA1P1 →	+0.026	+4.497	.004	.009	3	2
BLCA	HMGN1P34 →	+0.105	+5.018	<.001	.004	3	2
UCEC	WDR7-OT1 →	+0.066	+2.179	.005	.007	3	2
UCEC	RNU6-907P →	+0.235	+2.622	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,314 associations by consensus.

RNU6-589P by RNF215 expression — CESC

Explore this box plot interactively →