RNF215

Across TCGA pan-cancer cohorts, RNF215 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RNF215’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF215 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF215 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where RNF215 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF215 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+0.861	<.001	12	view →
KIRC	Female	III,IV	+0.617	<.001	12	view →
COAD	Female	All	+0.691	<.001	11	view →
LIHC	Female	II,III,IV	+1.188	<.001	9	view →
LUAD	All	All	+0.300	<.001	8	view →
BLCA	Female	All	+0.884	.001	6	view →
CHOL	Male	All	+1.823	<.001	5	view →
KICH	Female	All	−0.757	<.001	5	view →
LUSC	All	All	+0.530	<.001	5	view →
STAD	All	II,III,IV	+0.487	.003	4	view →
READ	All	All	+0.472	.003	4	view →
KIRP	All	IV	+0.595	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RNF215–HNSC

Open the HNSC breakdown →