RNA, U6 small nuclear 589, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-589P profile across patient tissues and cancer cell-line models. RNU6-589P expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, RNU6-589P is differentially expressed in 2, with the highest sampling consensus in KIRP. Additionally, RNU6-589P RNA expression shows 8,449 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, KIRP, and LSCC as cancer lineages where RNU6-589P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-589P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-589P survival associations across molecular data types. RNU6-589P RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-589P RNA expression–survival associations across cancer types. High RNU6-589P expression shows unfavorable associations in ACC, LUSC, LIHC and KIRP, but favorable associations in OV and STAD. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for RNU6-589P RNA expression.
This table summarizes RNU6-589P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-589P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-589P shows lower tumor expression in THCA and higher tumor expression in KIRP. The KIRP box plot shows higher RNU6-589P RNA expression in tumor versus normal tissue (log2 FC = +0.460, t-test p = .040).
This table shows molecular features associated with RNU6-589P in patient tissues and cancer cell lines. In patient samples, RNU6-589P shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
