RNF214

Across TCGA patient cohorts, RNF214 protein abundance is significantly associated with the RNA expression of many other genes, with 10,130 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF214-associated genes across cancer lineages are TMEM218, NKAPD1, and ZNF202. Each is linked with RNF214 in more than 7 cancer types. Because this analysis shows association rather than direction, both RNF214-to-partner and partner-to-RNF214 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF214 versus TMEM218 in BRCA, with a Pearson correlation of 0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF214→partner) and Y-score (partner→RNF214) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TMEM218 →	+0.455	+0.146	<.001	<.001	3	8
LSCC	NKAPD1 →	+0.567	+0.305	<.001	<.001	3	8
HNSC	ZNF202 →	+0.498	+0.242	<.001	<.001	3	8
HNSC	VPS26B →	+0.585	+0.244	<.001	<.001	3	7
HNSC	PAFAH1B2 →	+0.604	+0.236	<.001	<.001	3	7
HNSC	C11orf71 →	+0.792	+0.168	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,130 associations by consensus.

RNF214 vs TMEM218 — BRCA

Explore this scatter interactively →