RNF214

Across TCGA pan-cancer cohorts, RNF214 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNF214’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RNF214 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF214 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

LIHC, COAD, and HNSC are the cancer types where RNF214 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF214 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.028	<.001	9	view →
COAD	Male	II,III,IV	+0.477	<.001	7	view →
HNSC	All	All	+0.334	.004	6	view →
BRCA	Female	All	−0.334	<.001	6	view →
THCA	All	All	−0.302	.001	6	view →
STAD	All	II,III,IV	+0.451	.004	5	view →
LUAD	Male	All	+0.393	.001	4	view →
CHOL	All	All	+1.553	<.001	3	view →
KIRC	All	All	+0.204	.003	3	view →
LUSC	All	All	+0.203	.022	2	view →
KICH	Female	All	−0.427	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNF214–LIHC

Open the LIHC breakdown →