RNF19B

Across TCGA patient cohorts, RNF19B mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF19B-associated genes across cancer lineages are PEA-15_pS116, SF2, and Di-Ras3. Each is linked with RNF19B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF19B-to-partner and partner-to-RNF19B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by RNF19B-low versus RNF19B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF19B→partner) and Y-score (partner→RNF19B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PEA-15_pS116 →	+0.505	+3.321	.006	.010	3	1
UCEC	SF2 →	-0.136	-3.308	.018	.010	3	1
UCEC	Di-Ras3 →	-0.224	-3.321	.004	.010	3	1
UCEC	PI3K-p110-a →	-0.196	-3.321	.033	.010	1	1
UCEC	PRAS40_pT246 →	+0.277	+3.335	.002	.005	1	1
UCEC	c-Kit →	-0.255	-3.321	.036	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PEA-15_pS116 by RNF19B expression — UCEC

Explore this box plot interactively →