RNF19B

Across TCGA pan-cancer cohorts, RNF19B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNF19B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNF19B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF19B is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and STAD are the cancer types where RNF19B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF19B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.959	<.001	11	view →
KICH	Female	II,III,IV	−1.967	<.001	9	view →
STAD	All	II,III,IV	+0.871	.001	7	view →
LIHC	All	All	+0.555	<.001	7	view →
KIRC	All	All	+0.450	<.001	7	view →
CHOL	Male	All	+1.969	<.001	5	view →
THCA	Male	II,III,IV	+0.538	.003	5	view →
BRCA	All	II,III,IV	+0.396	<.001	4	view →
LUSC	All	All	+0.427	<.001	3	view →
UCEC	All	All	−0.866	.003	2	view →
LUAD	Female	All	+0.206	.013	2	view →
ESCA	All	All	+1.136	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNF19B–HNSC

Open the HNSC breakdown →