RNF19B

Across TCGA pan-cancer cohorts, RNF19B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RNF19B data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RNF19B RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNF19B expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, ACC, and LGG are the cancer types where RNF19B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.742	0.521	<.001	133	view →
ACC	DFS	Median	All	0.507	0.805	<.001	62	view →
LGG	DFS	Median	All	0.651	0.832	<.001	54	view →
LIHC	DFS	Median	All	0.462	0.624	<.001	49	view →
HNSC	DFS	Median	All	0.767	0.646	<.001	33	view →
READ	DFS	Quartile	II,III,IV	0.874	0.454	.006	28	view →
ESCA	DFS	Median	III,IV	0.559	0.320	.008	27	view →
CHOL	DFS	Median	All	0.743	0.139	.016	15	view →
THYM	OS	Median	All	0.921	1.000	.012	14	view →
UCS	DFS	Tertile	IV	0.942	0.488	.024	12	view →
PAAD	OS	Tertile	All	0.319	0.614	.030	12	view →
UCEC	OS	Quartile	III,IV	0.875	0.736	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RNF19B–KIRC (OS)

Open the KIRC breakdown →