RNF182

Across TCGA patient cohorts, RNF182 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF182-associated genes across cancer lineages are ATM, PCNA, and XBP1. Each is linked with RNF182 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF182-to-partner and partner-to-RNF182 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RNF182-low versus RNF182-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF182→partner) and Y-score (partner→RNF182) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.621	-3.906	<.001	<.001	3	3
COAD	PCNA →	+0.261	+3.008	.042	.019	3	2
COAD	XBP1 →	+0.296	+2.820	.002	.035	3	2
UCEC	eEF2 →	+0.379	+3.321	.003	.009	3	2
UCEC	INPP4B →	-0.350	-2.700	.002	.005	3	2
UCEC	Notch1 →	+0.167	+2.916	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by RNF182 expression — UCEC

Explore this box plot interactively →