RNF182

Across TCGA pan-cancer cohorts, RNF182 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNF182’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNF182 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF182 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LUAD are the cancer types where RNF182 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF182 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−1.514	<.001	12	view →
KICH	All	III,IV	−1.921	<.001	11	view →
LUAD	Female	III,IV	−2.034	<.001	8	view →
LUSC	All	III,IV	−1.886	<.001	7	view →
THCA	Male	III,IV	−0.957	<.001	7	view →
BLCA	All	All	+1.078	.007	6	view →
COAD	All	All	+0.456	.008	2	view →
PRAD	All	All	−0.311	<.001	2	view →
CHOL	All	All	+1.162	.026	1	view →
READ	All	All	+1.056	.047	1	view →
LIHC	Male	III,IV	−0.046	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNF182–KIRC

Open the KIRC breakdown →