RNF182

Across TCGA pan-cancer cohorts, RNF182 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RNF182 data layer compared with 8 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RNF182 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF182 expression acts as an unfavorable survival marker, although some lineages such as MESO and DLBC show a favorable association.

STAD, LUSC, and UCEC are the cancer types where RNF182 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Tertile	II,III,IV	0.379	0.671	.006	50	view →
LUSC	OS	Quartile	III,IV	0.293	0.688	<.001	45	view →
UCEC	DFS	Median	All	0.782	0.890	<.001	42	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	24	view →
BLCA	DFS	Median	All	0.192	0.472	.007	22	view →
MESO	OS	Median	III,IV	0.716	0.358	.021	14	view →
DLBC	DFS	Median	All	1.000	0.469	.014	13	view →
UCS	OS	Median	II,III,IV	0.619	0.355	.033	12	view →
LUAD	OS	Quartile	II,III,IV	0.275	0.548	.014	11	view →
SARC	OS	Median	All	0.651	0.798	.009	10	view →
CESC	DFS	Quartile	All	0.745	0.861	.027	10	view →
SKCM	DFS	Median	III,IV	0.505	0.770	.003	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RNF182–STAD (OS)

Open the STAD breakdown →