RNF182

Across TCGA cell cohorts, RNF182 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF182-associated genes across cancer lineages are DPRX, PRR23A, and LMOD2. Each is linked with RNF182 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF182-to-partner and partner-to-RNF182 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPRX grouped by RNF182-low versus RNF182-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF182→partner) and Y-score (partner→RNF182) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DPRX →	+0.040	+5.321	<.001	.005	3	1
CNS	PRR23A →	+0.031	+4.981	<.001	.008	3	1
LARGE_INTESTINE	LMOD2 →	+0.127	+3.643	.003	.005	3	1
LARGE_INTESTINE	ACSM6 →	+0.022	+3.584	<.001	.002	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LARGE_INTESTINE	PSMB11 →	+0.024	+2.878	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

DPRX by RNF182 expression — CNS

Explore this box plot interactively →