RNF169

Across TCGA patient cohorts, RNF169 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,548 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF169-associated proteins across cancer lineages are FAM76B_S193, CELF1, and FAM76B. Each is linked with RNF169 in more than 5 cancer types. Because this analysis shows association rather than direction, both RNF169-to-partner and partner-to-RNF169 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF169 versus FAM76B_S193 in PDAC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF169→partner) and Y-score (partner→RNF169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FAM76B_S193 →	+0.576	+0.278	<.001	.001	3	6
GBM	CELF1 →	+0.266	+0.316	.001	<.001	3	5
LSCC	FAM76B →	+0.384	+0.487	<.001	<.001	3	5
GBM	RBM12 →	+0.242	+0.225	<.001	<.001	3	5
HNSC	PCF11 →	+0.303	+0.677	<.001	<.001	3	5
GBM	RSF1 →	+0.380	+0.297	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,548 associations by consensus.

RNF169 vs FAM76B_S193 — PDAC

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