RNF169

Across TCGA pan-cancer cohorts, RNF169 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RNF169’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where RNF169 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF169 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

CHOL, LUSC, and THCA are the cancer types where RNF169 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF169 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	All	+1.736	<.001	5	view →
LUSC	Male	II,III,IV	+0.578	.005	4	view →
THCA	All	All	−0.525	<.001	4	view →
COAD	Male	All	+0.404	.009	4	view →
LIHC	All	All	+0.399	.001	4	view →
BRCA	All	II,III,IV	+0.254	.021	3	view →
UCEC	All	All	−0.634	.008	2	view →
LUAD	Male	All	+0.506	.018	2	view →
HNSC	All	All	+0.405	.027	2	view →
KIRC	All	All	+0.257	.007	2	view →
ESCA	Female	All	+0.813	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RNF169–CHOL

Open the CHOL breakdown →