RNF168

Across TCGA patient cohorts, RNF168 protein abundance is significantly associated with the RNA expression of many other genes, with 12,255 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RNF168-associated genes across cancer lineages are FAM86C2P, USH1G, and FAM83D. Each is linked with RNF168 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF168-to-partner and partner-to-RNF168 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF168 versus FAM86C2P in COAD, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF168→partner) and Y-score (partner→RNF168) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FAM86C2P →	+0.705	+0.644	<.001	.001	3	3
LSCC	USH1G →	+1.065	+0.540	<.001	<.001	3	3
LSCC	FAM83D →	+0.936	+0.445	<.001	<.001	3	3
HNSC	RAD51AP1 →	+0.632	+0.643	<.001	<.001	3	3
HNSC	LMNB1 →	+0.753	+0.608	.009	<.001	3	3
LSCC	SMC4 →	+0.761	+0.552	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,255 associations by consensus.

RNF168 vs FAM86C2P — COAD

Explore this scatter interactively →