RNF146

Across TCGA patient cohorts, RNF146 mutation is significantly associated with the RNA expression of many other genes, with 1,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF146-associated genes across cancer lineages are LINC01072, RN7SKP132, and RPL12P46. Each is linked with RNF146 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF146-to-partner and partner-to-RNF146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by RNF146-low versus RNF146-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF146→partner) and Y-score (partner→RNF146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.123	+2.208	<.001	.001	3	2
UCEC	RN7SKP132 →	+0.071	+3.069	<.001	.005	3	2
LUSC	RPL12P46 →	+0.353	+6.191	<.001	.001	3	2
CESC	DEFA5 →	+2.015	+4.934	.001	.002	3	1
CESC	GYG2P1 →	+0.045	+4.601	<.001	.004	3	1
CESC	RNU6-442P →	+0.232	+5.342	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,831 associations by consensus.

LINC01072 by RNF146 expression — UCEC

Explore this box plot interactively →