RNF146

Across TCGA pan-cancer cohorts, RNF146 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNF146’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNF146 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF146 is over-expressed in tumor, although a few such as LUSC and KICH show the opposite, repressed pattern.

LUSC, KICH, and LUAD are the cancer types where RNF146 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF146 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	III,IV	−0.906	<.001	9	view →
KICH	Female	All	−0.980	<.001	8	view →
LUAD	Female	II,III,IV	−0.621	<.001	8	view →
UCEC	All	All	−0.812	<.001	6	view →
BRCA	All	III,IV	−0.451	<.001	6	view →
CHOL	All	All	+1.072	<.001	4	view →
HNSC	Female	III,IV	+0.418	.025	2	view →
READ	All	III,IV	+0.255	.039	2	view →
LIHC	All	All	+0.229	.010	2	view →
BLCA	Male	IV	−0.785	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNF146–LUSC

Open the LUSC breakdown →