RNF122

Across TCGA patient cohorts, RNF122 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,516 significant associations in total. GBM shows the largest number of these associations.

The most reproducible RNF122-associated proteins across cancer lineages are PPP1R12A_S995, LAMC1, and SDC4. Each is linked with RNF122 in more than 4 cancer types. Because this analysis shows association rather than direction, both RNF122-to-partner and partner-to-RNF122 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RNF122 versus PPP1R12A_S995 in PDAC, with a Pearson correlation of 0.51.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF122→partner) and Y-score (partner→RNF122) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP1R12A_S995 →	+0.480	+0.438	<.001	<.001	3	5
OV	LAMC1 →	+0.415	+0.762	<.001	<.001	3	5
BRCA	SDC4 →	-0.659	-0.431	<.001	.002	3	5
COAD	CFH →	+0.665	+0.743	<.001	<.001	3	5
BRCA	COG7 →	-0.230	-0.495	<.001	<.001	3	5
COAD	GTPBP10 →	-0.404	-0.568	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,516 associations by consensus.

RNF122 vs PPP1R12A_S995 — PDAC

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