RNF122

Across TCGA pan-cancer cohorts, RNF122 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNF122’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNF122 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF122 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

KIRC, LUAD, and BLCA are the cancer types where RNF122 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF122 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.889	<.001	12	view →
LUAD	Male	All	−1.159	<.001	9	view →
BLCA	Male	All	−1.620	<.001	8	view →
LUSC	Male	II,III,IV	−1.395	<.001	8	view →
HNSC	All	All	+0.684	.001	7	view →
KICH	All	All	−0.993	<.001	5	view →
THCA	Female	All	−0.757	<.001	4	view →
BRCA	All	II,III,IV	−0.399	<.001	4	view →
CHOL	All	All	+1.482	<.001	2	view →
PAAD	All	All	−0.990	.008	2	view →
PRAD	All	All	−0.531	<.001	2	view →
LIHC	Male	All	−0.401	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNF122–KIRC

Open the KIRC breakdown →