RNF113B

Across TCGA patient cohorts, RNF113B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF113B-associated genes across cancer lineages are MEK1, Notch1, and TIGAR. Each is linked with RNF113B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF113B-to-partner and partner-to-RNF113B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RNF113B-low versus RNF113B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF113B→partner) and Y-score (partner→RNF113B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.441	+2.662	.001	<.001	3	2
UCEC	Notch1 →	+0.186	+2.232	<.001	.005	3	2
UCEC	TIGAR →	+0.129	+1.792	.024	.008	3	2
UCEC	ATM →	-0.422	-1.687	.013	.040	3	2
UCEC	14-3-3_beta →	-0.106	-2.432	.004	.018	3	1
UCEC	Heregulin →	-0.115	-1.415	.012	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by RNF113B expression — UCEC

Explore this box plot interactively →