RNF113B

Across TCGA pan-cancer cohorts, RNF113B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated RNF113B data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNF113B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF113B expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

ACC, BRCA, and DLBC are the cancer types where RNF113B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.384	0.814	<.001	81	view →
BRCA	DFS	Median	III,IV	0.938	0.818	<.001	72	view →
DLBC	DFS	Tertile	All	0.414	0.944	.001	39	view →
THCA	OS	Quartile	II,III,IV	0.941	0.990	.013	33	view →
SCLC	OS	Tertile	II,III,IV	0.894	0.548	.001	32	view →
SKCM	DFS	Median	II,III,IV	0.166	0.378	.010	25	view →
HNSC	DFS	Quartile	IV	0.525	0.329	.020	20	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	18	view →
BLCA	OS	Median	IV	0.690	0.485	.002	18	view →
KIRP	DFS	Median	II,III,IV	0.873	0.373	.014	14	view →
CHOL	DFS	Tertile	III,IV	0.118	0.476	.031	9	view →
UCS	OS	Median	IV	0.752	0.404	.013	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

RNF113B–ACC (OS)

Open the ACC breakdown →