RNF113B

Across TCGA cell cohorts, RNF113B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RNF113B-associated genes across cancer lineages are CFHR5, OR6C3, and ENPP6. Each is linked with RNF113B in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF113B-to-partner and partner-to-RNF113B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR5 grouped by RNF113B-low versus RNF113B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF113B→partner) and Y-score (partner→RNF113B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CFHR5 →	+0.013	+6.022	<.001	.001	3	1
SKIN	OR6C3 →	+0.026	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ENPP6 →	+0.036	+3.793	.004	.007	3	1
LARGE_INTESTINE	FAM205A →	+0.025	+4.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CFHR5 by RNF113B expression — SKIN

Explore this box plot interactively →