RNF103

Across TCGA patient cohorts, RNF103 mutation is significantly associated with the RNA expression of many other genes, with 2,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF103-associated genes across cancer lineages are DSCR4-IT1, RNA5SP413, and RCC1. Each is linked with RNF103 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF103-to-partner and partner-to-RNF103 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DSCR4-IT1 grouped by RNF103-low versus RNF103-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF103→partner) and Y-score (partner→RNF103) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	DSCR4-IT1 →	+0.443	+5.039	<.001	.008	3	3
LUSC	RNA5SP413 →	+0.567	+4.496	.003	.007	3	3
UCEC	RCC1 →	+0.440	+3.010	.001	<.001	3	2
UCEC	HARBI1 →	+0.423	+1.879	<.001	<.001	3	2
UCEC	PITPNB →	+0.327	+1.868	.004	<.001	3	2
UCEC	MRPS23 →	+0.390	+2.454	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,697 associations by consensus.

DSCR4-IT1 by RNF103 expression — READ

Explore this box plot interactively →