RNF103

Across TCGA pan-cancer cohorts, RNF103 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNF103’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNF103 RNA is repressed in tumor relative to normal tissue. In most cancer types RNF103 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

KICH, LIHC, and BLCA are the cancer types where RNF103 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF103 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.942	<.001	8	view →
LIHC	All	III,IV	+0.690	<.001	8	view →
BLCA	Male	All	−0.710	<.001	7	view →
UCEC	All	III,IV	−0.924	<.001	6	view →
COAD	Female	All	−0.882	<.001	6	view →
BRCA	All	All	+0.371	<.001	6	view →
KIRC	All	All	+0.222	.001	5	view →
READ	All	II,III,IV	−0.794	.008	3	view →
CHOL	All	All	+0.546	.001	3	view →
LUAD	All	All	+0.176	.031	3	view →
PRAD	All	All	+0.298	.004	2	view →
STAD	Male	II,III,IV	+0.406	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNF103–KICH

Open the KICH breakdown →