RNF10

Across TCGA cell cohorts, RNF10 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF10-associated genes across cancer lineages are TCP11X1, SPRR2B, and MS4A13. Each is linked with RNF10 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF10-to-partner and partner-to-RNF10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP11X1 grouped by RNF10-low versus RNF10-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF10→partner) and Y-score (partner→RNF10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TCP11X1 →	+0.017	+3.584	<.001	.005	3	1
STOMACH	SPRR2B →	+0.040	+5.285	<.001	.003	3	1
STOMACH	MS4A13 →	+0.133	+5.285	<.001	.003	3	1
LARGE_INTESTINE	GRM6 →	+0.057	+2.793	.001	.002	3	1
LUNG_SCLC	OR52E8 →	+0.040	+4.643	<.001	.004	3	1
LARGE_INTESTINE	RFX4 →	+0.026	+3.621	.007	.005	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TCP11X1 by RNF10 expression — URINARY_TRACT

Explore this box plot interactively →