RNF10

Across TCGA pan-cancer cohorts, RNF10 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNF10’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RNF10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF10 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

LIHC, BRCA, and KIRC are the cancer types where RNF10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.972	<.001	9	view →
BRCA	All	III,IV	+0.313	<.001	8	view →
KIRC	Male	II,III,IV	−0.443	<.001	7	view →
COAD	All	All	−0.252	<.001	7	view →
CHOL	Male	All	+1.541	<.001	5	view →
KICH	All	All	−0.377	.004	3	view →
THCA	Male	IV	−0.493	.032	2	view →
KIRP	Male	All	−0.414	.002	2	view →
PRAD	All	All	+0.189	.008	2	view →
HNSC	Female	III,IV	+0.291	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNF10–LIHC

Open the LIHC breakdown →