RNF10

Across TCGA pan-cancer cohorts, RNF10 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RNF10 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RNF10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNF10 expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

HNSC, LIHC, and SCLC are the cancer types where RNF10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.573	0.837	<.001	80	view →
LIHC	DFS	Median	All	0.457	0.622	<.001	75	view →
SCLC	OS	Median	All	0.648	0.327	<.001	67	view →
ACC	DFS	Tertile	All	0.358	0.742	<.001	60	view →
LGG	OS	Median	All	0.353	0.550	<.001	54	view →
BLCA	DFS	Quartile	All	0.238	0.518	.002	53	view →
LUAD	DFS	Median	II,III,IV	0.596	0.763	.001	42	view →
KICH	OS	Tertile	III,IV	0.323	1.000	.002	23	view →
READ	DFS	Quartile	III,IV	0.384	0.870	.002	21	view →
BRCA	OS	Tertile	III,IV	0.886	0.743	.006	17	view →
COAD	DFS	Median	III,IV	0.477	0.636	.011	14	view →
KIRP	OS	Median	III,IV	0.505	0.773	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RNF10–HNSC (OS)

Open the HNSC breakdown →