RNASET2

Across TCGA patient cohorts, RNASET2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASET2-associated genes across cancer lineages are FASN, ACC1, and 4E-BP1. Each is linked with RNASET2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASET2-to-partner and partner-to-RNASET2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RNASET2-low versus RNASET2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASET2→partner) and Y-score (partner→RNASET2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.532	+3.169	.002	.019	3	2
UCEC	ACC1 →	+0.499	+2.183	.002	.033	3	2
UCEC	4E-BP1 →	+0.406	+3.169	<.001	.018	3	2
UCEC	14-3-3_beta →	-0.107	-3.143	.018	.018	3	1
UCEC	eIF4G →	+0.282	+2.999	.044	.035	3	1
UCEC	p62 Lck ligand →	+0.482	+3.331	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FASN by RNASET2 expression — UCEC

Explore this box plot interactively →