RNASET2

Across TCGA pan-cancer cohorts, RNASET2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RNASET2 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RNASET2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNASET2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

SKCM, KIRP, and LGG are the cancer types where RNASET2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.454	0.268	<.001	87	view →
KIRP	DFS	Median	IV	0.036	0.596	<.001	62	view →
LGG	OS	Median	All	0.341	0.562	<.001	52	view →
KIRC	DFS	Median	All	0.537	0.720	<.001	48	view →
LIHC	OS	Median	All	0.456	0.666	<.001	39	view →
ACC	DFS	Tertile	II,III,IV	0.359	0.832	<.001	37	view →
OV	OS	Tertile	III,IV	0.801	0.911	.005	34	view →
LUAD	DFS	Tertile	III,IV	0.449	0.862	.002	29	view →
BLCA	DFS	Tertile	II,III,IV	0.681	0.537	.010	27	view →
HNSC	OS	Quartile	III,IV	0.830	0.682	.016	19	view →
SARC	OS	Quartile	All	0.610	0.393	.024	14	view →
ESCA	DFS	Tertile	IV	0.242	0.704	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RNASET2–SKCM (OS)

Open the SKCM breakdown →