RNASET2

Across TCGA pan-cancer cohorts, RNASET2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNASET2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNASET2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASET2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, KIRP, and THCA are the cancer types where RNASET2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASET2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+3.649	<.001	12	view →
KIRP	All	IV	+3.025	<.001	11	view →
THCA	Male	III,IV	−1.315	<.001	11	view →
STAD	Male	All	+1.357	<.001	8	view →
LIHC	Female	II,III,IV	+0.959	<.001	8	view →
KICH	Male	All	−1.109	<.001	7	view →
BRCA	All	All	+0.488	<.001	6	view →
COAD	All	All	+0.437	<.001	6	view →
HNSC	All	All	+0.397	.010	5	view →
LUAD	All	All	+0.389	<.001	5	view →
CHOL	All	All	+1.635	<.001	3	view →
READ	Female	All	+0.434	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNASET2–KIRC

Open the KIRC breakdown →