Across TCGA patient cohorts, RNASEK mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEK-associated genes across cancer lineages are YWHAQP7, SNORD31B, and RNU6-1297P. Each is linked with RNASEK in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEK-to-partner and partner-to-RNASEK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEK→partner) and Y-score (partner→RNASEK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	YWHAQP7 →	+0.145	+3.892	.008	.004	3	1
UCEC	SNORD31B →	+0.398	+4.582	.001	.005	3	1
UCEC	RNU6-1297P →	+0.586	+3.993	.001	.001	3	1
UCEC	MIR4692 →	+0.469	+4.453	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

RNASEK survival (RNA) · tumor vs normal (RNA) · all RNASEK data types