RNASEH2A

Across TCGA patient cohorts, RNASEH2A mutation is significantly associated with the RNA expression of many other genes, with 1,058 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH2A-associated genes across cancer lineages are GAPDHP56, SKA1, and ZMYND19. Each is linked with RNASEH2A in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2A-to-partner and partner-to-RNASEH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDHP56 grouped by RNASEH2A-low versus RNASEH2A-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2A→partner) and Y-score (partner→RNASEH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	GAPDHP56 →	+0.094	+6.257	<.001	.001	3	2
SKCM	SKA1 →	+0.872	+3.478	<.001	.002	3	2
UCEC	ZMYND19 →	+0.496	+2.839	<.001	.001	3	2
UCEC	TCF3 →	+0.601	+3.191	.001	.009	3	2
UCEC	NUTF2 →	+0.382	+3.201	.005	.009	3	2
UCEC	ACD →	+0.658	+2.839	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,058 associations by consensus.

GAPDHP56 by RNASEH2A expression — READ

Explore this box plot interactively →