RNASEH2A

Across TCGA patient cohorts, RNASEH2A mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASEH2A-associated genes across cancer lineages are PCNA, ERK2, and VHL. Each is linked with RNASEH2A in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASEH2A-to-partner and partner-to-RNASEH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by RNASEH2A-low versus RNASEH2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2A→partner) and Y-score (partner→RNASEH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.282	+2.999	.006	.035	3	2
UCEC	ERK2 →	+0.216	+3.000	.020	.036	3	1
UCEC	VHL →	-1.479	-3.169	<.001	.018	3	1
UCEC	Bak →	+0.303	+3.321	.012	.010	3	1
UCEC	beta-Catenin →	+0.506	+2.459	.038	.020	3	1
UCEC	Cyclin-B1 →	+0.759	+3.169	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by RNASEH2A expression — UCEC

Explore this box plot interactively →