RNASEH2A

Across TCGA cell cohorts, RNASEH2A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,377 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RNASEH2A-associated GO terms across cancer lineages are Regulation of nuclear division, Regulation of mitotic nuclear division, and Nuclear chromosome segregation. Each is linked with RNASEH2A in more than 19 cancer types. Because this analysis shows association rather than direction, both RNASEH2A-to-partner and partner-to-RNASEH2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of nuclear division grouped by RNASEH2A-low versus RNASEH2A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASEH2A→partner) and Y-score (partner→RNASEH2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of nuclear division →	+0.135	+1.458	<.001	<.001	3	20
OESOPHAGUS	Regulation of mitotic nuclear division →	+0.144	+1.210	.008	.003	3	20
OESOPHAGUS	Nuclear chromosome segregation →	+0.160	+1.156	.002	.002	3	20
SOFT_TISSUE	Positive regulation of cell cycle process →	+0.109	+1.186	<.001	<.001	3	20
SOFT_TISSUE	Regulation of chromosome segregation →	+0.139	+1.241	<.001	<.001	3	20
PANCREAS	Cell cycle DNA replication initiation →	+0.255	+1.619	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,377 associations by consensus.

Regulation of nuclear division by RNASEH2A expression — SOFT_TISSUE

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