RNASE8

Across TCGA patient cohorts, RNASE8 mutation is significantly associated with the RNA expression of many other genes, with 358 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible RNASE8-associated genes across cancer lineages are RNU6-668P, OFD1P10Y, and MIR7702. Each is linked with RNASE8 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE8-to-partner and partner-to-RNASE8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-668P grouped by RNASE8-low versus RNASE8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE8→partner) and Y-score (partner→RNASE8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-668P →	+0.228	+7.816	<.001	.008	3	2
LUSC	OFD1P10Y →	+0.059	+7.924	<.001	.008	3	2
UCEC	MIR7702 →	+0.415	+5.253	<.001	.001	3	2
LUSC	RNU1-14P →	+0.684	+7.924	<.001	.008	3	2
LUSC	RNU6-622P →	+1.088	+7.924	<.001	.008	3	2
LUSC	RNU6-1151P →	+0.544	+7.924	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 358 associations by consensus.

RNU6-668P by RNASE8 expression — SKCM

Explore this box plot interactively →