RNASE8

Across TCGA pan-cancer cohorts, RNASE8 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated RNASE8 data layer compared with 3 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RNASE8 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNASE8 expression acts as an unfavorable survival marker, although some lineages such as ACC and GBM show a favorable association.

SKCM, ACC, and GBM are the cancer types where RNASE8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Tertile	III,IV	0.337	0.622	.008	36	view →
ACC	DFS	Tertile	All	0.867	0.405	.022	21	view →
GBM	DFS	Tertile	All	0.416	0.227	.012	18	view →
DLBC	DFS	Tertile	All	0.399	0.796	.032	18	view →
SCLC	OS	Tertile	All	0.082	0.822	<.001	18	view →
LUAD	DFS	Tertile	IV	0.333	0.671	.048	18	view →
ESCA	OS	Tertile	III,IV	0.653	0.353	.031	14	view →
LGG	OS	Quartile	All	0.802	0.903	.004	13	view →
OV	DFS	Quartile	IV	0.251	0.493	.006	12	view →
CHOL	DFS	Tertile	II,III,IV	0.114	0.479	.009	9	view →
LIHC	OS	Tertile	III,IV	0.435	0.664	.022	6	view →
SARC	DFS	Tertile	All	0.666	0.445	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

RNASE8–SKCM (DFS)

Open the SKCM breakdown →