RNASE8

Across TCGA pan-cancer cohorts, RNASE8 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNASE8’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNASE8 RNA is repressed in tumor relative to normal tissue. In most cancer types RNASE8 is over-expressed in tumor, although a few such as LUSC and ESCA show the opposite, repressed pattern.

LUSC, ESCA, and STAD are the cancer types where RNASE8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASE8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−0.079	.001	3	view →
ESCA	All	II,III,IV	−0.105	.002	2	view →
STAD	All	II,III,IV	+0.059	.007	2	view →
BRCA	All	III,IV	−0.057	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RNASE8–LUSC

Open the LUSC breakdown →