RNASE2

Across TCGA patient cohorts, RNASE2 mutation is significantly associated with the RNA expression of many other genes, with 1,025 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNASE2-associated genes across cancer lineages are MIR8053, RNA5SP377, and RNA5SP458. Each is linked with RNASE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNASE2-to-partner and partner-to-RNASE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by RNASE2-low versus RNASE2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNASE2→partner) and Y-score (partner→RNASE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR8053 →	+0.297	+4.743	<.001	.005	3	2
LUAD	RNA5SP377 →	+0.697	+4.888	<.001	<.001	3	2
SKCM	RNA5SP458 →	+0.524	+5.179	<.001	<.001	3	2
LUAD	FAM230C →	+1.207	+4.010	<.001	.003	3	2
LUSC	RNA5SP528 →	+0.532	+3.814	.008	.009	3	2
UCEC	SNORD116-23 →	+0.879	+2.525	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,025 associations by consensus.

MIR8053 by RNASE2 expression — SKCM

Explore this box plot interactively →