RNASE2

Across TCGA pan-cancer cohorts, RNASE2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RNASE2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNASE2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNASE2 is over-expressed in tumor.

KIRC, KIRP, and THCA are the cancer types where RNASE2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNASE2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.878	<.001	12	view →
KIRP	Male	All	+1.708	<.001	11	view →
THCA	Male	II,III,IV	+1.348	<.001	11	view →
COAD	All	III,IV	+0.921	<.001	11	view →
HNSC	All	III,IV	+0.746	<.001	11	view →
BLCA	All	IV	+1.011	.005	7	view →
STAD	Female	All	+1.509	<.001	6	view →
LUAD	Female	All	+1.022	<.001	6	view →
BRCA	All	All	+0.722	<.001	6	view →
UCEC	All	All	+0.481	.033	4	view →
CHOL	Female	All	+0.543	.019	2	view →
ESCA	All	All	+1.148	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RNASE2–KIRC

Open the KIRC breakdown →